The San Francisco 49ers will be without wide receiver Mike Evans for a third straight game Sunday after ruling him out against the Dallas Cowboys as he continues to deal with Achilles tendinitis.
Meanwhile, it remains unclear whether standout left tackle Trent Williams will suit up after injuring his shoulder in practice this week.
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Injuries are an unavoidable part of the NFL, but few teams have dealt with them as consistently as the San Francisco 49ers have in recent seasons. Their injury report has become a weekly storyline.
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San Francisco 49ers receiver Mike Evans (5) walks off the field with an apparent injury during the second quarter against the Washington Commanders at Levi’s Stadium on Oct. 19, 2026 in Santa Clara, California. (Thearon W. Henderson/Getty Images)
Evans and Williams were not the only concerns for San Francisco this week. Coach Kyle Shanahan said cornerbacks Deommodore Lenoir and Renardo Green were also on the injury report. Both missed practice Wednesday and Thursday after suffering injuries in last week’s game against Las Vegas, but they were limited participants Friday.
Linebacker Dre Greenlaw was also listed as questionable after hurting his knee at practice Thursday, while cornerback Nate Hobbs (adductor), defensive back Upton Stout (shoulder, neck) and defensive tackle C.J. West (knee) were also questionable.
At 38, Williams remains a 12-time Pro Bowler playing at a high level, making his availability significant for San Francisco. He left practice early Thursday and did not participate Friday, but Shanahan remained hopeful the veteran tackle would feel well enough to play Sunday.
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San Francisco 49ers offensive lineman Trent Williams (71) lines up during the first quarter of an NFL game against the Las Vegas Raiders at Levi’s Stadium on Nov. 8, 2026, in Santa Clara, California. (Getty Images)
Vederian Lowe would likely start if Williams is unable to go, but replacing the longtime standout would be a major challenge for the 49ers.
“The left tackle in general is always huge. Then a guy of Trent’s caliber is huge,” Shanahan said. “Just the way he plays out there, down in and down out, what he means to the team, just his presence, the type of person he is, and just what he brings on game day. He’s a captain for a reason, and everyone knows Trent Williams is one of the best players in this league.”
San Francisco 49ers head coach Kyle Shanahan looks on during a game against the Seattle Seahawks at Lumen Field on Oct. 11, 2026, in Seattle, Washington. (Alika Jenner/Getty Images)
San Francisco will have more help at receiver this week with Deebo Samuel set to return after missing the past three games with a hamstring injury and Keenan Allen set to make his debut for the 49ers after being acquired earlier this week in a trade from Indianapolis.
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But they will be missing Evans again after he left a Week 6 game against Washington early with the injury. He missed the next two games and has been unable to practice since then but is making progress. Shanahan said there’s a chance Evans could play next week in Mexico against Minnesota.
The 49ers enter Sunday’s game with an NFC-best 7-1 record.
The Associated Press contributed to this report.