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Some older adults may be able to stop taking statins with little added risk over two years, but a new study raises concerns about longer-term safety.
That’s according to a randomized clinical trial that was presented on Nov. 7, 2026, at the American Heart Association Scientific Sessions in Chicago, and published in The New England Journal of Medicine.
Statins are prescription medications that lower LDL, or “bad,” cholesterol by reducing how much cholesterol the liver makes. They are known to help reduce the risk of heart attack and stroke, according to the National Heart, Lung and Blood Institute.
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The study — conducted by researchers from the University of Bern in Switzerland, the University of California, San Francisco, and other institutions — included 1,880 adults aged 70 years and older, all of whom were taking statins to prevent a first heart attack or stroke.
Some older adults may be able to stop taking statins with little added risk over two years, but a new study raises concerns about longer-term safety. (iStock)
All participants had at least two chronic medical conditions, but did not have established cardiovascular disease or previous cardiovascular events. Half of the participants stopped taking statins, and the other half continued.
After two years, the added risk from stopping statins was small enough to fall within the limits researchers had set for the study. However, that did not mean stopping carried no added risk.
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Over the full follow-up, which lasted about two years for the typical participant and up to four years for some, about 13% of those assigned to stop statins had a heart attack, an ischemic stroke or died from any cause, compared with 9% assigned to continue treatment.
The study’s safety monitoring board also recommended that participants who were assigned to stop statins discuss restarting treatment with their healthcare team, according to the American College of Cardiology.
Statins are prescription medications that lower LDL, or “bad,” cholesterol by reducing how much cholesterol the liver makes. (iStock)
For other outcomes, the researchers found no meaningful differences between the two groups in reported quality of life, muscle pain, falls or loss of muscle mass and strength.
Dr. Christopher Kelly, a UNC Health cardiologist, emphasized that continuing statins did not worsen reported muscle pain or quality of life in the trial.
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Although guidelines support lowering high cholesterol earlier in life, the benefits of continuing statins in older age are less certain, said study author Dr. Rita F. Redberg, a cardiology professor at the University of California, San Francisco, in a press release.
“This small, increased risk of cardiovascular events means that one cannot make a general recommendation about stopping statins in this patient population.”
Earlier studies found no difference in mortality after adults 70 and older stopped statins for primary prevention, she noted.
“One study suggested quality of life improvements after stopping statins,” Redberg said, adding that her team explored whether stopping was safe for older adults taking the drugs to prevent a first cardiovascular event.
Study limitations
The study had several limitations. About 14% of participants did not stick with their assigned treatment plan. Some who were told to stop taking statins resumed them, while others assigned to continue treatment stopped taking the drugs, according to the researchers.
The findings also may not apply to all older adults, as the study was limited to people aged 70 and older who had multiple chronic health conditions but no history of heart disease or stroke.
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Although some participants were followed for up to four years, the study primarily assessed outcomes over about two years. Longer follow-up is needed to determine how stopping statins affects patients over many years.
Weighing the risks
“This small, increased risk of cardiovascular events means that one cannot make a general recommendation about stopping statins in this patient population,” Redberg said.
“There should be shared decision-making between the patient and the healthcare professional to know if it is appropriate for an individual to discontinue the medication,” the researcher said. (iStock)
“There should be shared decision-making between the patient and the healthcare professional to know if it is appropriate for an individual to discontinue the medication. In general, however, discontinuation is safe for most people who are in this age group and without a previous CVD event.”
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Kelly, who was not involved in the study, noted that a healthy 70-year-old could live another 20 years, leaving questions about the effects of stopping treatment over that longer period.
The doctor also emphasized individualized decisions based on overall health and expected lifespan, noting that he “errs on the side of caution” with his own patients.
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“I typically recommend that they continue taking it unless they have specific concerns about that medication, such as side effects, or if they are taking a lot of medicines, and they’re just really eager to stop taking one of them.”