Novak Djokovic heads to Court Philippe-Chatrier to face Swiss Henri Laaksonen, who is competing in the second round in Paris for the first time.
Djokovic entered the competition as the World No 1 and is aiming for a 16th Grand Slam at Roland Garros.
Victory in Paris will see the 32-year-old equal his achievement during 2016 when the held all four majors at the same time.
Although Federer and Nadal have more Grand Slam titles than Djokovic, with 20 and 17 respectively, neither of them have managed the feat of holding all four at the same time.
If the Serbian wins the French Open he will become only the second man in the history of the sport to hold all four Grand Slam trophies at the same time twice – Rod Laver won all four majors in 1962 and 1969.
In the first round Djokovic dispatched Hubert Hurkacz in straight sets on Monday 6-4, 6-2, 6-2 to reach the second round and the Serbian insisted he was pleased to have a “quality” opponent in his first match, as he prepares to take on Laaksonen.
“I like the fact that I had a very good, quality opponent in the first round,” Djokovic said.
“Because that gets me going with the right intensity from the start. I’m focused, I’m determined, and sharp from the blocks.”
How to watch the French Open on TV
The French Open is being shown on ITV 4 and Eurosport in the UK, with coverage starting from May 26.
ITV 4’s coverage will be fronted by John Inverdale, while Mark Petchey, Fabrice Santoro and Marion Bartoli will join him.
ITV will show around 140 hours of action across the two weeks and their live coverage today begins from 10am and runs until 8.30pm.
Djokovic’s clash with Laaksonen today will start no earlier than 12pm UK time, with the match second up on Court Suzanne-Lenglen.
Alternatively, you can watch the tournament on Eurosport 1 and Eurosport 2 if you have a Sky, BT Sport or Virgin subscription.