There were small slip ups in his speech again on Sunday, as Biden referred to the ballot box as “the battle box” and called his Republican opponent “former Trump”, though his message of unity for the country was clear.
“Tonight I’m asking every American to recommit,” the Democrat said, adding: “Hate must have no safe harbor.”
The Oval Office is seen as among the most solemn settings for a Presidential address, and is usually reserved for moments of national emergency or mourning.
Biden noted that the Republican National Convention begins on Tuesday and said he would be returning to campaigning.
It comes after Trump narrowly escaped death on Saturday after a shooter opened fire at a Republican rally in Pennsylvania.
Trump suffered a bloody injury to his ear as gunshots rang out during the campaign stop.
As secret service agents swarmed around the 78-year-old, Trump was photographed defiantly clenching his fist into the air showing remarkable composure having just survived an attempt on his life.
Others weren’t as lucky, with one killed in the horrific attack and two others left in a critical condition.
The attacker, who the FBI have named 20-year-old Thomas Matthew Crooks, of Bethel Park, Pennsylvania, was killed during the assassination attempt.
Biden repeated his condemnation of the shooting on Sunday, saying: “A former president was shot and American citizen killed or simply for exercising his freedom to support the candidate of his choosing.”
Reminding Americans of the stakes in the national vote, Biden said the election is “going to shape the for decades to come. I believe that with all my soul.”
Biden is travelling to Las Vegas on Monday before addressing the 115th NAACP National Convention the following day, with a campaign event scheduled for Wednesday.
Meanwhile, Trump is already back in action, and arrived in Milwaukee on Sunday night for his party’s convention during which he’ll be named the GOP presidential nominee.
He too emphasised the need for unity in the wake of the attack, telling the Washington Examiner: “This is a chance to bring the whole country, even the whole world, together.
“The speech will be a lot different, a lot different than it would’ve been two days ago,” he added.