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Joe Manganiello survived “multiple near-death experiences” over a seven-year battle with his health.
In his upcoming memoir, “Bloodlines,” Manganiello detailed his experiences with a life-threatening medical scare, which led him “beyond medicine and into a remarkable, globe-spanning quest that revealed answers about his ancestry, inherited trauma and the deeper histories we carry,” according to Simon & Schuster.
Manganiello, 49, endured a “cascade of autoimmune-related illnesses,” that impacted his skin, thyroid, eyes, lungs and digestive system.
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Joe Manganiello fought for his life and endured a seven-year health battle after suffering debilitating medical setbacks. (Michael Simon)
During the seven-year medical ordeal, Manganiello battled “chronic pain, a life-saving organ amputation, existential crisis and a prolonged fight for survival that left doctors with few answers and no clear explanation.”
As he struggled to not only survive, but also to find answers to his medical issues, the “Magic Mike” star pursued an unorthodox path.
Manganiello enlisted the help of “shamans, pagan rituals, ancient myths, long-lost family records and the rebirth of his own spirituality” in an attempt to cure his illness.
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Through researching his own genealogy, Manganiello discovered family members who survived the Armenian genocide, “ancestors shaped by violence and displacement, and the hidden patterns shared by others living with chronic illness.”
Joe Manganiello pursued unconventional methods to cure his chronic illness. (Daniele Venturelli/Getty Images)
“It was the most brutally difficult time of my life, one I wouldn’t wish on my worst enemy, but also my greatest adventure,” Manganiello told People in a statement.
“I hope that what I went through on this journey can give readers hope that answers and healing may lie for them on the other side of whatever they are fighting through.”
He added, “The process of writing this book gave me the gift of perspective that helped me to see that my suffering was a cocoon from which I would emerge forever changed.”
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Last year, Manganiello and his fiancée, Caitlin O’Connor, left Los Angeles behind for their shared hometown of Pittsburgh, Pennsylvania.
Joe Manganiello and Caitlin O’Connor smile and wear matching leather jackets while standing on a football field in their home state. (Caitlin O’Connor)
“I mean, L.A. has been both of our homes for over 20 years. I was born in L.A., but raised in Pittsburgh, so we’re both from the same hometown,” she told People magazine.
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O’Connor explained that their shared roots were something they initially bonded over, and they’re both thrilled to be “back home.”
“That’s what we really connect on, you know. We share the same upbringing, the same hometown knowledge. And that’s what really connects us as a couple.”
Joe Manganiello and Caitlin O’Connor were engaged in the summer of 2025. (Getty Images)
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Manganiello and O’Connor first sparked romance rumors in September 2023 and confirmed their relationship a few months later. They announced their engagement on Instagram in October 2025 and noted that the actual proposal occurred that June.
In July 2023, Manganiello and Sofía Vergara announced that they were getting divorced after seven years of marriage.
Sofía Vergara and Joe Manganiello walk the red carpet at an Oscar party. Both listed “irreconcilable differences” as their basis for divorce in papers obtained by Fox News Digital. (Presley Ann/Actors)
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“We have made the difficult decision to divorce. As two people that love and care for one another very much, we politely ask for respect of our privacy at this time as we navigate this new phase of our lives,” the couple said in a joint statement at the time.
Fox News Digital’s Janelle Ash contributed to this report.